ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of mild hypothermia on cerebral oxygen partial pressure, carbon dioxide partial pressure, pH and body temperature (PbrO2, PbrCO2, pHbr and BT) in patients with acute severe head injury.</p><p><b>METHODS</b>Thirty-eight patients with acute severe head injury were treated with mild hypothermia, meantime PbrO2, PbrCO2, pHbr and BT were monitored in order to study the changes of PbrO2, PbrCO2, pHbr and BT.</p><p><b>RESULTS</b>In patients with acute head injury, mild hypothermia obviously increased PbrO2, decreased PbrCO2 and CO2 accumulation and acidosis in brain tissue. BT was 1-1.5 deg. higher than rectal temperature (RT) after injury. The BT and RT were decreased when the patients were treated with mild hypothermia, but at the same time the difference between BT and RT was increased.</p><p><b>CONCLUSIONS</b>In patients with acute severe head injury the direct monitoring of PbrO2, PbrCO2, pHbr and BT was safe and reliable, and is helpful in estimating prognosis and mild hypothermia therapy.</p>
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Acute Disease , Biomarkers , Blood , Body Temperature , Physiology , Brain Injuries , Diagnosis , Mortality , Therapeutics , Carbon Dioxide , Blood , Follow-Up Studies , Glasgow Coma Scale , Hydrogen-Ion Concentration , Hypothermia, Induced , Injury Severity Score , Monitoring, Physiologic , Methods , Oxygen , Blood , Probability , Risk Assessment , Survival Rate , Treatment OutcomeABSTRACT
Objective:to collect and summary mental disturbance caused by severe craniocerebral injury Method:to compare 150 cases of mental disturbance caused by severe craniocerebral injury with those (20 cases) with similar injury but without mental disturbance Result:1) The rate of those with mental disturbance in patients with severe craniocerebral injuries was 20 8% The rate of that in all patients of head injury was 5 2% 2) 107 of our sample (71 3%, 107/150) had sub-arachnoid hemorrhage 27 had fracture at the base of skull 3) Compared with those without mental disturbance, the occurrence of mental symptoms closely related to severity of injury 4) Delirium was the early symptom, while memory deficiency and affective disorder were common on the later stages Conclusion:Patients with brain contusion with subarachnoid hemorrhage are more likely having mental disturbance